Christian Yelich delivered a walk-off grand slam in the 10th inning to give the Milwaukee Brewers a 5-1 comeback victory over visiting Boston on Tuesday, the fourth consecutive loss for the Red Sox.

The blast to right-center off Liam Hendricks (0-2) was Yelich’s 10th homer of the year and first career walk-off home run.

Yelich helped the Brewers tie the game 1-1 with a run in the ninth off Aroldis Chapman. He doubled, stole third and scored on Sal Frelick’s line-drive single.

Rob Zastryzny (1-0) stranded a runner at third in the top of the 10th. Red Sox starter Richard Fitts came off the injured list and threw three scoreless innings.

Astros 11, Athletics 1

Jose Altuve produced his second multi-homer game in less than a week, while Hunter Brown delivered his American League-leading ninth quality start as Houston rolled over the slumping Athletics.

Altuve finished 4-for-4 with three RBIs and notched his 40th career four-hit game. Jeremy Pena went 2-for-5 with a home run, two runs scored and two RBIs. Christian Walker hit a two-run homer. Hunter Brown (7-3) allowed one run on six hits with eight strikeouts over six innings.

JP Sears allowed nine runs on 10 hits over 3 1/3 innings for the Athletics, who have lost 12 of 13.

Pirates 9, Diamondbacks 6

Bryan Reynolds capped a four-hit game with a go-ahead homer in Pittsburgh’s seven-run eighth inning as the Pirates overcame a six-run deficit to beat Arizona in Phoenix.

Reynolds hit a three-run homer with one out in the eighth off Jalen Beeks to break a tie at 6-6. The Pirates got five runs in the inning off Kevin Ginkel (0-3).

Henry Davis had a two-run homer and a double and Tommy Pham and Alexander Canario had two hits apiece for the Pirates. For the Diamondbacks, Corbin Carroll homered and Corbin Burnes pitched seven innings of two-run ball.

Cubs 4, Rockies 3 (11 innings)

Rookie Matt Shaw blooped a walk-off single to right field in the 11th inning to propel Chicago over visiting Colorado.

After Brenton Doyle’s RBI groundout gave the Rockies a 3-2 lead in the top of the 11th, Michael Busch tied the game with an RBI single off Tyler Kinley (0-2), who then walked Nico Hoerner and surrendered Shaw’s game-winning single.

Chris Flexen (3-0) pitched the 10th and 11th innings for the Cubs, allowing an unearned run. Doyle homered and drove in two for the Rockies, who have lost nine of their past 10 games.

Yankees 3, Angels 2

Carlos Rodon threw seven scoreless innings, Ben Rice and Oswald Peraza homered and New York held on to beat Los Angeles in Anaheim, Calif.

Rodon (7-3) struck out 10 and didn’t walk a batter while permitting five hits. The left-hander retired 13 consecutive Angels hitters between the third and seventh innings, helping the Yankees earn their fourth win in a row.

The Angels made things interesting in the ninth inning against Yankees reliever Devin Williams, scoring twice on three hits, including a leadoff home run from Yoan Moncada. Williams, though, was able to register his fifth save.

Padres 8, Marlins 6

Luis Arraez stroked three hits, knocking in the tying and go-ahead runs, as San Diego rallied from a 6-0 first-inning deficit to top visiting Miami.

San Diego finished with 13 hits, getting three from Xander Bogaerts as well as two each from Cronenworth and Tatis. Stephen Kolek (3-1) became the first major league starter since Bartolo Colon in 1999 to give up six earned runs in the first inning and still win. Kolek allowed six hits, five in the first inning, in 5 1/3 innings.

Miami starter Max Meyer lasted only 3 1/3 innings, yielding seven hits and six runs, four earned. Marlins second baseman Ronny Simon committed three errors in the first four innings and was charged with another before the official scorer gave Bogaerts an RBI single in the third.

Rangers 2, Blue Jays 0

Josh Jung singled home the deciding run with two outs in the eighth inning as Texas did just enough to beat Toronto in Arlington, Texas.

Six Rangers pitchers combined on a four-hit shutout despite starter Nathan Eovaldi leaving after two innings with what the team termed as right triceps fatigue. Jung delivered his game-winning hit off Blue Jays reliever Chad Green (1-1). Robert Garcia struck out two in the ninth for his third save.

The Blue Jays have scored a combined four runs in their past five games, losing four of those contests. Toronto starter Bowden Francis pitched five-plus scoreless innings.

Mariners 9, Nationals 1

Cal Raleigh hit two home runs, taking the American League lead with 19, and Julio Rodriguez also went deep as Seattle defeated visiting Washington.

Rookie Logan Evans (3-1) allowed one run on four hits over eight innings for the Mariners, who had lost three of their previous four games. Rodriguez and Dylan Moore each had three hits.

James Wood homered for the Nationals, who had won six of their previous eight games. Mitchell Parker (4-4) gave up four runs on seven hits over 4 2/3 innings.

Reds 7, Royals 2

Elly De La Cruz hit a pair of long homers and Brady Singer delivered a quality start for Cincinnati in his return to Kansas City.

Tyler Stephenson also went deep and TJ Friedl recorded his fifth straight multi-hit game for the Reds, who have totaled 14 runs while taking the first two of the three-game set. Singer (6-3), who spent his first five seasons with the Royals before being traded to Cincinnati in November, allowed just two runs over seven innings.

Jonathan India, who was swapped by the Reds to get Singer, had two hits with an RBI and Maikel Garcia extended his hitting streak to 12 games for the Royals.

Cardinals 7, Orioles 4

Nolan Arenado broke a tie with an eighth-inning home run and Lars Nootbaar also homered as St. Louis defeated host Baltimore.

Masyn Winn drove in two runs and Jordan Walker tripled in a three-run eighth inning as the Cardinals racked up 14 hits, including three by Nootbaar. St. Louis has won four of its past five games.

The Orioles had a season-best three-game winning streak snapped despite Ryan O’Hearn’s three-run home run. Ryan Mountcastle notched three hits, including a pair of doubles, and Ramon Urias had two hits, but Baltimore went 1-for-14 with runners in scoring position.

Tigers 3, Giants 1

Jack Flaherty allowed just two hits in six scoreless innings as host Detroit downed San Francisco.

Flaherty (3-6) struck out eight in the Tigers’ third straight victory. Will Vest picked up his seventh save despite giving up a ninth-inning run. Riley Greene had three hits, including two doubles, and drove in two runs, and Wenceel Perez, activated from the injured list, homered in his first at-bat of the season.

Wilmer Flores drove in the lone run for the Giants. Logan Webb (5-5) gave up three runs on seven hits while striking out 10 in six innings. San Francisco manager Bob Melvin was ejected in the fifth inning for arguing balls and strikes.

Dodgers 9, Guardians 5

Shohei Ohtani belted his major-league-leading 20th homer and Max Muncy added a three-run shot as visiting Los Angeles beat Cleveland.

Ohtani cleared the wall in left field in the fourth inning — his third homer in as many games — for a two-run shot off Tanner Bibee, and Muncy homered in the ninth. Michael Conforto hit a solo homer and Andy Pages had a pair of RBI singles. Dustin May (3-4) struck out a season-high nine over five innings.

Daniel Schneemann had a three-run homer in the fourth for the Guardians and Jose Ramirez extended his career-best hitting streak to 20 games, the franchise’s longest since Jason Kipnis’ 20-game streak in 2015. Gabriel Arias doubled in a pair of runs in the ninth.

Phillies 2, Braves 0

Ranger Suarez fanned eight over six innings as Philadelphia blanked visiting Atlanta to earn its 10th win in 11 games.

Suarez (4-0) allowed four hits and three walks, and Jordan Romano pitched the ninth inning for his seventh save. Bryce Harper left after being hit by a pitch in the first inning, but X-rays on his right elbow were negative. Max Kepler cracked an RBI double in the second and J.T. Realmuto drew a bases-loaded walk in the eighth.

Braves starter Spencer Strider (0-3) allowed just one run and one hit in 4 2/3 innings. Ozzie Albies extended his hitting streak to 12 games with a sixth-inning single.

Twins 4, Rays 2

Joe Ryan tossed six strong innings and Kody Clemens hit a 415-foot homer, lifting Minnesota to the win over host Tampa Bay.

Ryan (5-2) allowed one run on five hits in a matchup against the franchise that selected him in the 2018 draft. Brooks Lee drove in an early run on a sacrifice fly for the Twins, and Ty France added an RBI single in the eighth. Carlos Correa collected three hits.

Jonathan Aranda had an RBI single and joined Brandon Lowe with two hits for the Rays, who saw their six-game winning streak come to a halt.

Mets 6, White Sox 4

Pete Alonso and Jared Young each hit two-run homers in the first inning and host New York withstood a late comeback attempt by Chicago to get the win.

Tylor Megill (4-4) combined with three relievers on an eight-hitter for the Mets, who have won four straight. Megill allowed two runs on four hits over 5 2/3 innings, and Reed Garrett earned his second save with 1 2/3 hitless innings.

Miguel Vargas homered and finished with three RBIs for the White Sox, who have dropped three in a row. Jonathan Cannon gave up five runs on nine hits over 5 2/3 innings.